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Spravato Treatment for Depression

What is Spravato? What is the process like? Learn more here.

For people who have depression, regularly meeting with a psychotherapist and/or taking antidepressants can relieve the symptoms. InspirationHATC now offers Spravato, an FDA-approved intranasal esketamine for treatment-resistant depression.

What is treatment-resistant depression?

Have you unsuccessfully tried…

  • Multiple medications for depression
  • Psychotherapy, group therapy, lifestyle modifications?
  • Complementary medicine alternatives or other specialty treatments?

If so, there’s a chance that you’re living with treatment-resistant depression.

What is Spravato?

Spravato is a nasal spray that introduces esketamine into your body. It creates the opportunity for the ketamine to go to work in your brain.

Spravato works differently than oral antidepressants. The ketamine targets the N-methyl-D-aspartate (NMDA) receptor. Studies show that this receptor is linked to major depressive disorder and stimulating it can deliver rapid antidepressant effects.

Does Spravato replace oral antidepressants?

Spravato does not replace your oral antidepressant, but rather works alongside it.

What is the process like for taking Spravato?

Spravato is taken under supervision due to side effects such as mild dissociation. After taking it, you will typically stay for monitoring for two hours. 

During your first month of taking Spravato, you will take it twice a week. Most patients see significant improvements in their depressive symptoms during this time.

After the first month, Spravato treatments may occur further apart, such as every one to two weeks. You will work with your provider to develop a plan that is best suit for your needs, helping you reduce and/or eliminate your depressive symptoms.

Contact IHAT to learn more.


Who is eligible for Spravato treatment?

Spravato is specifically designed for adults with treatment-resistant depression (TRD). This means that individuals who have not responded well to at least two different antidepressants may be eligible for Spravato treatment. It’s essential to consult with a healthcare professional to determine if Spravato is an appropriate option for your specific needs.

How long does it take for Spravato to work?

Unlike most traditional antidepressants, Spravato is known for its rapid onset of action. Some patients may experience relief from depressive symptoms within hours, while others may notice improvements within a few days of starting treatment. However, individual experiences may vary, and it’s crucial to follow your healthcare professional’s guidance regarding treatment duration and frequency.

Can Spravato be used in conjunction with other antidepressants?

Yes, Spravato is often prescribed as an add-on treatment to an existing oral antidepressant regimen. This combination has been shown to improve the overall effectiveness of depression treatment. However, it’s crucial to consult with your healthcare provider before combining Spravato with other medications to ensure safety and monitor for potential drug interactions.

Are there any restrictions or precautions while using Spravato?

Due to its potential side effects, such as dizziness and feelings of dissociation, patients should not drive, operate heavy machinery, or engage in other activities that require alertness for at least 24 hours after each Spravato treatment session. Additionally, it is essential to inform your healthcare provider of any medical conditions, medications, or supplements you are taking before starting Spravato treatment.

Is Spravato covered by insurance?

Coverage for Spravato treatment varies depending on your insurance plan and provider. Many insurance companies provide coverage for Spravato as a treatment option for TRD, but it’s essential to contact your insurance provider to verify coverage and any out-of-pocket expenses you may be responsible for.